COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world’s largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Containing nearly 24 million genomic variants across nearly 6,800 precise forms of human cancer, COSMIC provides variant scientists and bioinformaticians with an expert-curated database to:
Learn how to use COSMIC to avoid mutational consequences in cancer drug development and profile the mutational signatures of cancer therapies in clinical samples with Dr. Kyle Nilson. The session is followed by a Q&A session with COSMIC curator Steven Jupe.
What treatment options are available or under investigation for your cancer patients?
Get the answers with COSMIC Actionability, which has the latest data on the availability and development of drugs targeting specific somatic mutations in cancer, including lung, breast, melanoma, ovarian and colon cancer.
COSMIC was created with high-precision manual curation methods by PhD-level experts.
COSMIC is updated quarterly to ensure you remain informed on the latest findings.
Over the last five releases:
Access meticulously curated data on key cancer genes, merged with genome-wide annotations from 45,178 publications and open-access data from TCGA and ICGC.
Every data point is:
COSMIC is designed to provide ease-of-use and maximum flexibility. Users have full control of how they search, visualize and manipulate the data for specific panels and/or pipelines.
Learn how COSMIC and the Human Somatic Mutation Database (HSMD) provide clinical NGS testing labs with trusted data to identify and annotate biomarkers, assess their biological and clinical relevance, and support clinical trial matching and molecular tumor board (MTB) recommendations.
How to search by gene, cancer type, and mutation Here, we show you how to search COSMIC for a gene, cancer type, and mutation using BRAF as an example.
The accurate identification and annotation of somatic variants rely on the accuracy and depth of reference databases. In this on-demand webinar, learn how to use COSMIC to annotate gene variants using the world’s most comprehensive resource of up-to-date scientific evidence to find biological connections in somatic variants with manually curated findings.